JNCI study finds pharmaceutical
stop smoking aids ineffective
When is an aid not an aid?
A prospective study released yesterday by the Journal of the National Cancer Institute reports a "lack of effectiveness of pharmaceutical aids in increasing long-term cessation."
University of California at San Diego researchers examined matched data sets involving 2,129 smokers who attempted to quit and participated in the national Tobacco Use Supplement to the Current Population Survey (TUS-CPS).
Matched samples were used to create a more balanced comparison. Researchers found "no evidence that use of varenicline [Chantix], or bupropion [Zyban] or nicotine replacement [the nicotine patch, gum or lozenge] increased the probability of 30 days or more smoking abstinence at one-year follow-up."
The burning question is, with more than a dozen population level studies screaming the ineffectiveness of over-the-counter replacement nicotine, how much longer before the CDC and FDA begin alerting smokers to the truth, that pharma's OTC nicotine is not medicine or therapeutic?
On December 11, 2017 the FDA announced creation of EveryTryCounts.gov. There, the FDA's final crave coping tip falsely tells smokers to "Try nicotine replacement therapy (NRT), such as gums or patches. Using NRT can double your chance of quitting for good."
Clearly the FDA and CDC must realize that their "your" chances assertions attest to effectiveness, not clinical efficacy. Who benefits by deceiving smokers? And why did pharmaceutical products prevail in clinical trials yet fall flat on their face in real-world use?
The CDC and FDA know that "free medicine" was almost always dangled as clinical study recruiting bait. They know that placebo-controlled clinical trials were not blind as claimed; that 3 to 4 times as many assigned to placebo could correctly declare their assignment as could not, and that they could do so within 24 to 48 hours (peak withdrawal).
And they surely realize that the timing and focus of clinical trial counseling was intended to foster successful dependency transfer to, and use of, the product being tested, not the insights needed to aid the placebo arm in successfully navigating abrupt nicotine cessation.
The burning question remains, how many more millions of smokers must die before the CDC and FDA at last ask the most important question of all.
The question? In that each and every year more nicotine addicts arrest their chemical dependence upon nicotine by going cold turkey than by all other methods combined, what is the key to successful abrupt nicotine cessation?
- 07/18/18 - Cold turkey clobbers e-cigs, NRT and Chantix - John R. Polito
- 12/22/17 - JNCI study finds pharmaceutical stop smoking aids ineffective - John R. Polito
- 03/16/15 - Nicotine cessation: lost in the deserts of Abu Dhabi - John R. Polito
- 01/01/15 - 10 studies screaming "leave replacement nicotine alone!" - John R. Polito
- 01/20/14 - The Surgeon General's Reports: 50 years of cessation ignorance - John R. Polito
- 11/30/13 - Australia's half-baked quit smoking campaign - John R. Polito
- 11/18/13 - The Great American quit smoking sham - John R. Polito
- 10/19/13 - BMJ's non-publication policy should extend to pharma's nicotine - John R. Polito
- 08/26/13 - Gallup Poll: cold turkey 48 times smarter than Nicorette - John R. Polito
- 07/15/13 - Cold turkey quitting still king - John R. Polito
- 06/21/13 - My personal views on Chantix - Joel Sptizer
- 08/20/12 - Pharma bias destroys ITC quit smoking medication study - John R. Polito
- 03/17/12 - Potent warnings, horrible quitting advice: what's the CDC smoking? - John R. Polito
- 02/11/12 - Replacement Nicotine's Killing Fields - John R. Polito
- 12/22/11 - Chantix study joins negative findings omissions club - John R. Polito
- 11/14/11 - Dying truths about quitting smoking methods - John R. Polito
- 11/03/11 - Bias against cold turkey quitting apparent in literature - Michael Siegel, MD
- 11/03/11 - Suicidal behavior and depression in smoking cessation treatments - Moore TJ et al
- 11/01/11 - Study finds cold turkey quitting more effective but concludes opposite - Moore TJ et al
- 08/08/11- Tar wars over smoking cessation - , - BMJ Link - Professor Simon Chapman
- 06/14/11 - Is a 14% Chantix success rate worth risking death? - John R. Polito
- 03/30/11 - Chantix fails to defeat nicotine patch - John R. Polito
- 01/28/11 - Chantix serious injuries exceed 8,500 - John R. Polito
- 01/06/11 - Champix - Chantix worth questioned - John R. Polito
- 11/02/10 - GlaxoSmithKline Continues Defrauding Smokers - John R. Polito
- 08/08/10 - Little communication in failed war against smoking - John R. Polito
- 03/24/10 - Smokefree.gov really Buymeds.now - John R. Polito
- 12/29/09 - Five facts Chantix ads keep hidden - John R. Polito
- 10/22/08 - Pfizer's Chantix Continues Killing Quitters - John R. Polito
- 06/12/08 - Chantix and Champix mental health safety assurances contrary to evidence - John R. Polito
- 05/13/08 - Chantix blamed for 3,063 serious injuries and 78 deaths - John R. Polito
- 05/21/08 - Strong Safety Signal Seen for New Varenicline Risks - ISMP
- 05/13/08 - U.S. quit smoking policy integrity drowns in pharmaceutical influence - John R. Polito
- 05/05/08 - Does updated tobacco treatment "Guideline" reflect sham science? - John R. Polito
- 04/03/08 - FDA pulls video clip admitting Chantix suicide link - John R. Polito
- 04/02/08 - New FDA Chantix suicide risk video clip raises concerns - John R. Polito
- 02/29/08 - FDA Chantix Handling Betrayed Public Health - John R. Polito
- 10/19/07 - Video: WhyQuit's candid views on Chantix & Champix - Joel Spitzer
- 09/19/07 - Can Chantix Cause Depression? - - The People's Pharmacy,
- 03/12/07 - Flawed research equates placebo to cold turkey - John R. Polito
- 02/08/07 - Nicotine Fix - Behind Antismoking Policy, Influence of Drug Industry - Kevin Helliker
- 02/08/07 - WSJ Highlights Financial Conflicts of Chair of Federal Guidelines Panel - Michael Siegel, MD
- 03/07/07 - Nixing the Patch: Smokers quit cold turkey - Ken Millstone
- 03/01/07 - Nicotine for the Fetus, the Infant and Adolescent - - H.K. Ginzel, MD
- 02/19/07 - New Study Challenges Thinking on Use of NRT During Pregnancy - Michael Siegel, MD
- 01/07/07 - The secret to quitting smoking - John R. Polito
- 01/25/07 - Financial Ties Between Guideline Panels and Big Pharma Run Deep - Michael Siegel, MD
- 12/16/06 - Chantix - an 8 in 10 failure rate or worse? - John R. Polito
- 12/07/06 - Do physician's have a legal duty to ignore Guideline Recommendation 7? - John R. Polito
- 10/29/06 - Is the U.S. government's quitting policy killing smokers? - John R. Polito
- 08/25/06 - Will Chantix really help me quit smoking? - John R. Polito
- 07/12/06 - Conference Sponsorship by Pharma Precludes Objective Symposium - Michael Siegel, MD
- 07/10/06 - 13th World Conference on Tobacco or Health Drenched in Nicotine - John R. Polito
- 05/19/06 - Cold Turkey Twice as Effective as NRT or Zyban - John R. Polito
- 04/18/06 - Nicotine Not Medicine, Its Use Not Therapy - John R. Polito
- 12/13/05 - GlaxoSmithKline Attacks Cold Turkey Quitting - John R. Polito
- 12/29/05 - UK Guidance for NRT use in pregnancy and by children - ASH London
- 05/??/05 - June 2000 Guideline Chairman Michael Fiore's Testimony - see PDF pages 14 & 15 -
- 04/04/05 - The Nicotine Patch, Gum and Lozenge - Mounting Evidence of a Sham - John R. Polito
- 10/18/04 - 40 Years of Progress? - Joel Spitzer
- 05/19/04 - Widespread Blinding Failures Put NRT Studies in Serious Question - John R. Polito
- 05/17/04 - Nicotine Gum Maker's Concern Raises Concerns - John R. Polito
- 05/02/04 - A Quitter's Dilemma: Hooked on the Cure - Petra Bartosiewicz
- 04/27/04 - Quebec CT Quitters Disprove "Double Your Chances" NRT Assertion - John R. Polito
- 11/25/03 - Quitting Methods - Who to Believe? - Joel Spitzer
- 07/18/03 - Is CT Quitting More Productive & Effective than NRT? - John R. Polito
- 06/11/03 - Are Teens Getting Hooked on NRT? - John R. Polito
- 03/05/03 - March 2003 OTC NRT Meta-Analysis Finds 93% Midyear Relapse Rate - John R. Polito
- 02/18/03 - Are nicotine weaning products a bad joke? - John R. Polito
- 09/11/02 - JAMA Study Concludes NRT is Ineffective - John R. Polito
- 06/30/02 - Real-World Nicotine Patch and Gum Rates - John R. Polito
- 04/08/02 - Does the OTC Nicotine Patch Really Double Your Chances of Quitting? - John R. Polito
- 11/14/00 - Is Nicotine Replacement Therapy The Smoker's Last Best Hope? - John R. Polito
- 06/28/00 - Financial Disclosures for June 2000 Guideline Panel - U.S. Public Health Service
- 06/28/00 - June 2000 Guideline Recommendation 7 - pharmacotherapy use by all quitters - U.S. Public Health Service
- 10/15/97 - Glaxo Wellcome's objectives in creating UW Foundation million dollar endowed chair for Michael Fiore - Glaxo Wellcome
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